Sharaf-El-Deen, S., El-Sobky, M., Sadek, G., El- Aswad, B., Atallah, A., Yassien, R., Ammar, A. (2023). Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis. Parasitologists United Journal, 16(3), 246-252. doi: 10.21608/puj.2023.236678.1222
Shaimaa Sharaf-El-Deen; Mona El-Sobky; Gehan Sadek; Bahaa El- Aswad; Amira Atallah; Rania Yassien; Amany Ammar. "Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis". Parasitologists United Journal, 16, 3, 2023, 246-252. doi: 10.21608/puj.2023.236678.1222
Sharaf-El-Deen, S., El-Sobky, M., Sadek, G., El- Aswad, B., Atallah, A., Yassien, R., Ammar, A. (2023). 'Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis', Parasitologists United Journal, 16(3), pp. 246-252. doi: 10.21608/puj.2023.236678.1222
Sharaf-El-Deen, S., El-Sobky, M., Sadek, G., El- Aswad, B., Atallah, A., Yassien, R., Ammar, A. Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis. Parasitologists United Journal, 2023; 16(3): 246-252. doi: 10.21608/puj.2023.236678.1222
Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis
1Departments of Medical Parasitology, Faculty of Medicine, MenoufiaUniversity,Egypt
2Departments of Medical Parasitology, Faculty of Medicine, Menoufia University
3Departments of Medical Parasitology Faculty of Medicine, Menoufia University,Egypt, and King Salman International University, KSA
4Departments of Histopathology , Faculty of Medicine, Menoufia University
5Departments of Medical Parasitology , Faculty of Medicine, Menoufia University
Abstract
Background: Most drugs used for the treatment of trichinosis showed a limited bioavailability, and induced adverse side effects on administrating high doses. Therefore, there is a need to develop new agents to improve the bioavailability of these drugs. Objective: To assess the efficacy of metformin (MTF) administration as a co-drug with ALZ to treat muscular trichinosis. Material and Methods: A total of 25 mice were divided into five equal groups, categorized as negative control group, and four T. spiralis-infected groups: positive control, MTF-treated group, ALZ-treated group, and combined MTF-ALZ-treated group. Larval burden, muscle histopathology, new vascular formation by measuring CD34, and expression of the gene encoding myogenin (Myog) by real time PCR were investigated at the end of the experiment 35th day post-infection (dpi). Results: The results demonstrated that the group treated with MTF plus ALZ had the best outcome among all parameters, followed by the group treated with MTF, and finally the group treated with ALZ. Both MTF with ALZ proved to be a promising combination for the treatment of muscular trichinosis in experimentally-infected mice. Conclusion: It was concluded that MTF reduced the pathology of muscular phase of trichinosis. Further studies are recommended to better understand MTF pharmacokinetics.
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