Mohamed, S., Abdelmksoud, H., Sabry, H., Mahmoud, S., El Komi, W., Abu Shousha, T., El-Ashkar, A. (2023). Cholagogue additive effect of ursodeoxycholic acid to Praziquantel on murine schistosomiasis mansoni: Parasitological and histopathological studies. Parasitologists United Journal, 16(1), 32-40.
Shaimaa Mohamed; Hagar Abdelmksoud; Hoda Sabry; Soheir Mahmoud; Wafaa El Komi; Tarek Abu Shousha; Ayman El-Ashkar. "Cholagogue additive effect of ursodeoxycholic acid to Praziquantel on murine schistosomiasis mansoni: Parasitological and histopathological studies". Parasitologists United Journal, 16, 1, 2023, 32-40.
Mohamed, S., Abdelmksoud, H., Sabry, H., Mahmoud, S., El Komi, W., Abu Shousha, T., El-Ashkar, A. (2023). 'Cholagogue additive effect of ursodeoxycholic acid to Praziquantel on murine schistosomiasis mansoni: Parasitological and histopathological studies', Parasitologists United Journal, 16(1), pp. 32-40.
Mohamed, S., Abdelmksoud, H., Sabry, H., Mahmoud, S., El Komi, W., Abu Shousha, T., El-Ashkar, A. Cholagogue additive effect of ursodeoxycholic acid to Praziquantel on murine schistosomiasis mansoni: Parasitological and histopathological studies. Parasitologists United Journal, 2023; 16(1): 32-40.
Cholagogue additive effect of ursodeoxycholic acid to Praziquantel on murine schistosomiasis mansoni: Parasitological and histopathological studies
1Departments of Medical Parasitology, Theodor Bilharz Research Institute, Giza
2epartments of Medical Parasitology, Theodor Bilharz Research Institute, Giza
3Departments of Pathology, Theodor Bilharz Research Institute, Giza
4Departments of Medical Parasitology, College of Medicine, University of Bisha, Bisha, KSA
Abstract
Background: One of the considerable challenges of schistosomiasis chemotherapy is the inefficacy of praziquantel (PZQ) at the initial phase of the infection. Objective: The aim of this work is to evaluate the possible additive effect of ursodeoxycholic acid (UDCA) as a cholagogue with PZQ on experimental schistosomiasis mansoni. Material and Methods: Thirty mice were divided into 5 groups, 6 mice each; GI: non-infected, negative control; GII: infected nontreated, positive control; GIII: infected, treated with UDCA; GIV: infected, treated with PZQ; and GV: infected, treated with UDCA and PZQ. Parasitological and histopathological examinations were used as efficacy parameters. Results: There was a statistically significant difference between GII and the infected treated groups regarding the reduction of worm burden in the liver and mesenteric vessels, the presence of different developmental stages of S. mansoni ova in the intestinal wall, the mean total count of ova in the tissues of infected mice (P<0.001). At the same time, GV showed the best result by reducing the worm burden by 100%, the least number of immature and mature ova in the intestinal wall, the highest percentage of reduction of total ova count in the tissues of infected mice (90.09%), and the least mean granuloma diameter and number. Conclusion: UDCA has an auspicious additive effect to PZQ to decrease the worm burden, and the load of ova in both the intestinal wall and other tissues, and to decrease the number and diameter of granulomas due to infection with S. mansoni.
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