Zaki, W., Salem, H., Elazizy, H., Ajeeby, M. (2019). CD14 promotor polymorphisms associated with different allergic phenotypes and modulated with house dust mite allergy. Parasitologists United Journal, 12(1), 26-33. doi: 10.21608/puj.2019.7917.1031
Wafaa Zaki; Hedayat Salem; Hoda Mohammed Elazizy; Maryam Ebido Ajeeby. "CD14 promotor polymorphisms associated with different allergic phenotypes and modulated with house dust mite allergy". Parasitologists United Journal, 12, 1, 2019, 26-33. doi: 10.21608/puj.2019.7917.1031
Zaki, W., Salem, H., Elazizy, H., Ajeeby, M. (2019). 'CD14 promotor polymorphisms associated with different allergic phenotypes and modulated with house dust mite allergy', Parasitologists United Journal, 12(1), pp. 26-33. doi: 10.21608/puj.2019.7917.1031
Zaki, W., Salem, H., Elazizy, H., Ajeeby, M. CD14 promotor polymorphisms associated with different allergic phenotypes and modulated with house dust mite allergy. Parasitologists United Journal, 2019; 12(1): 26-33. doi: 10.21608/puj.2019.7917.1031
CD14 promotor polymorphisms associated with different allergic phenotypes and modulated with house dust mite allergy
3Clinical pathology,faculty of medicine,Cairo university, Cairo, Egypt and Medical Biology.
4Medical Biochemistry, Faculty of Medicine, Cairo University, Egypt.
5Faculty of medicine, Jazan university, Jazan,KSA.
Abstract
Background: House dust mite (HDM) constitutes a major cause of allergic disease all over the world; meanwhile interaction between genetic control, environmental factors in the context of allergen exposure may affect allergic phenotype. Cluster of Differentiation 14 (CD14) polymorphisms play a major role in genetic control of allergic phenotype. Objective: We aimed to assess the role of CD14 genetic polymorphisms at two loci A(-1,145)G, and G(-1,359)T in expression of atopic asthma and allergic rhinitis in the context of HDM exposure in Jazan, KSA. Subjects and Methods: Through a case control study, 160 subjects served as 60 atopic asthmatic patients, 40 allergic rhinitis patients and 60 healthy non-allergic controls. Clinical and immunological parameters for the studied subjects were assessed. Then, genotyping of two single nucleotide polymorphisms (SNPs) at A(-1,145)G, and G(-1,359)T, in the promoter region of the CD14 gene was conducted using restriction fragment length polymorphisms (RFLP-PCR). Results: The present study showed that in HDM sensitive subjects there was a significant association between GG genotype variant at A(-1,145)G with atopic asthma patients and another significant association between TT genotype variant at G(-1,359)T with allergic rhinitis patients. Conclusion: The impact of allergy induced by HDMs may be enhanced in individuals with specific CD14 gene variants resulting in exaggerated allergic phenotype.
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