Document Type : Original Article
Authors
1
Departments of Medical Parasitology , Faculty of Medicine, Zagazig,University, Zagazig 44519, Egypt, Division of Pediatric Urology
2
Departments of Pediatrics , Faculty of Medicine, Zagazig,University, Zagazig 44519, Egypt, Division of Pediatric Urology,
3
Department of Surgery, Children's Hospital of Eastern Ontario, University of Ottawa, Ontario K1H 8L1, Canada
4
Departments of Medical Parasitology Faculty of Medicine, Zagazig,University, Zagazig 44519, Egypt, Division of Pediatric Urology,
Abstract
Background: Toxoplasmosis is a universal opportunistic infection that causes severe complications in
immunosuppressed patients. Renal failure is a state of immunodeficiency, especially in children. Therefore,
hemodialysis patients may be at high risk for toxoplasmosis.
Objective: To investigate the seropositivity rate of T. gondii specific antibodies (anti-T. gondii IgM and IgG
antibodies) in pediatric hemodialysis patients.
Subjects and Methods: ELISA was used to test serum samples from 67 children on regular hemodialysis
and 50 healthy controls for anti-Toxoplasma IgG and IgM antibodies in this case-control research.
Demographic criteria, duration of hemodialysis, and possible risk factors for toxoplasmosis were recorded.
All participants were clinically examined to detect any signs suggestive of toxoplasmosis.
Results: In comparison to total T. gondii seropositivity in all participants (23%), it was 16% and 28% in
control and hemodialysis groups, respectively. The IgG antibodies were detected in 19 hemodialysis cases
and eight control cases. The mean duration of hemodialysis among T. gondii seropositive and seronegative
patients were 47.6±14.3 and 22.3±6.7 months, respectively. Among T. gondii seropositive individuals, the
average duration of hemodialysis was substantially longer. In the examined groups, contact with cats and
eating semi-cooked meat were the risk factors recorded for T. gondii seropositivity.
Conclusion: Toxoplasmosis seropositivity rate was higher in hemodialysis children than in the control
group. For early identification and treatment, T. gondii screening should be done for all hemodialysis
patients before and during hemodialysis
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