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El Saftawy, E., Hamed, A., Sameh, A., Sarhan, R. (2021). Perceptions on therapeutic modalities regarding the virulence and immunity of cutaneous leishmaniasis. Parasitologists United Journal, 14(3), 229-243. doi: 10.21608/puj.2021.95583.1132
Enas El Saftawy; Ahmed Hamed; Ahmed Sameh; Rania Sarhan. "Perceptions on therapeutic modalities regarding the virulence and immunity of cutaneous leishmaniasis". Parasitologists United Journal, 14, 3, 2021, 229-243. doi: 10.21608/puj.2021.95583.1132
El Saftawy, E., Hamed, A., Sameh, A., Sarhan, R. (2021). 'Perceptions on therapeutic modalities regarding the virulence and immunity of cutaneous leishmaniasis', Parasitologists United Journal, 14(3), pp. 229-243. doi: 10.21608/puj.2021.95583.1132
El Saftawy, E., Hamed, A., Sameh, A., Sarhan, R. Perceptions on therapeutic modalities regarding the virulence and immunity of cutaneous leishmaniasis. Parasitologists United Journal, 2021; 14(3): 229-243. doi: 10.21608/puj.2021.95583.1132

Perceptions on therapeutic modalities regarding the virulence and immunity of cutaneous leishmaniasis

Article 2, Volume 14, Issue 3, December 2021, Page 229-243  XML PDF (1.05 MB)
Document Type: Review Article
DOI: 10.21608/puj.2021.95583.1132
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Authors
Enas El Saftawy1; Ahmed Hamed2; Ahmed Sameh3; Rania Sarhan email orcid 4
1Departments of Medical Parasitology, Faculties of Medicine, Cairo Universities, Armed Forces College of Medicine, Cairo, Egypt
2Departments of Medical Parasitology, Faculties of Medicine, Armed Forces College of Medicine , Cairo, Egypt
3Departments of Medical Parasitology, Faculties of Medicine, Armed Forces College of Medicine, Cairo, Egypt
4Departments of Medical Parasitology, Faculties of Medicine, Ain Shams Universities, Armed Forces College of Medicine , Cairo, Egyp
Abstract
Despite the wide variety of Leishmania spp. virulence, the present repertoire of drugs has limited effects, showing increased resistance. The effect depends on host immune factors which differ between immunocompetent and immunocompromised patients, and among various clinical forms of the disease. Recently, metallocomplexes have been increasingly shown to be potent delivery systems for conventional treatments. Additionally, lasers were suggested as an efficacious treatment tool due to their potentials in the clinical applications and resolution of the disease. This review suggests that the promising leishmanicidal activity of the metallocomplexes and laser treatment comprise a new hopeful alternative in the search for definitive cutaneous leishmaniasis (CL) cure.
Keywords
: cutaneous leishmaniasis, leishmanial drug resistance; laser, metallocomplexes, virulence factors
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