Alhusseiny, S., El-Beshbishi, S. (2021). Nuclear factor-kappa B signaling pathways and parasitic infections: An overview. Parasitologists United Journal, 14(3), 218-228. doi: 10.21608/puj.2021.91389.1129
Samar Alhusseiny; Samar El-Beshbishi. "Nuclear factor-kappa B signaling pathways and parasitic infections: An overview". Parasitologists United Journal, 14, 3, 2021, 218-228. doi: 10.21608/puj.2021.91389.1129
Alhusseiny, S., El-Beshbishi, S. (2021). 'Nuclear factor-kappa B signaling pathways and parasitic infections: An overview', Parasitologists United Journal, 14(3), pp. 218-228. doi: 10.21608/puj.2021.91389.1129
Alhusseiny, S., El-Beshbishi, S. Nuclear factor-kappa B signaling pathways and parasitic infections: An overview. Parasitologists United Journal, 2021; 14(3): 218-228. doi: 10.21608/puj.2021.91389.1129
Nuclear factor-kappa B signaling pathways and parasitic infections: An overview
Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura 35516- Egypt
Abstract
Host nuclear factor-kappa B (NF-κB) transcription factor plays a pivotal role in innate immunity and resistance to infection. It induces the expression of several genes that encode pro-inflammatory cytokines. It also participates in regulating the differentiation and survival of innate immune cells and lymphocytes. Infection of host cells with pathogens usually activates host NF-κB signaling pathways. The majority of parasites evolved diverse protective mechanisms against NF-κB activity to shield their continued existence. Herein, we present brief insights into NF-κB signaling pathways, activators and inhibitors, and the main subsequent events following protozoan and helminthic infections in vitro, as well as in vivo either in experimental models, or in humans. Understanding the underlying mechanisms of NF-κB activation and inhibition may be of great help as a therapeutic strategy against different parasitic infections.
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